Chlorotoxin peptide-functionalized polyethylenimine-entrapped gold nanoparticles for glioma SPECT/CT imaging and radionuclide therapy

Improved biocompatibility of surface functionalized dendrimer- entrapped gold nanoparticles{

Gold nanoparticles (NPs) have recently received immense scientific and technological interest because of their extensive applications in biology, catalysis, and nanotechnology. In most of these applications, the gold NP surfaces are modified with different functionalities. For instance, alkanethiol and alkylamine molecules are used for phase transfer of gold NPs, and oligonucleotide molecules a...

Peptide ligation catalyzed by functionalized gold nanoparticles.

Spider Toxin Peptide Lycosin-I Functionalized Gold Nanoparticles for in vivo Tumor Targeting and Therapy

Cell penetrating peptides (CPPs) are commonly utilized for intracellular delivery of functional materials to circumvent biomembrane barrier. However, further application of CPPs is hindered by lacking selectivity toward targeted cells. The spider venom peptide, lycosin-I, is a CPP with potent cytotoxicity to cancer cells, which might enable lycosin-I to deliver functional materials into cancer ...

Cellular imaging of endosome entrapped small gold nanoparticles

Small gold nanoparticles (sAuNPs, <10 nm in a core diameter) have been used for drug delivery and cancer therapy due to their high payload to carrier ratio. Information about the amount and location of sAuNPs in cells and tissues is critical to many applications. However, the current detection method (i.e., transmission electron microscopy) for such sAuNPs is limited due to the extensive sample...

Applications of gold nanoparticles for medical imaging

Background & Aim: Molecular imaging enables us to non-invasively visualize tissue microstructures and lesion characterization, allowing accurate diagnosis of diseases at early stages. A successful molecular imaging requires a nontoxic contrast agent with high sensitivity. Nowadays, a wide range of nanoparticles have been developed as contrast agents for medical imaging modalities. Here, we revi...